Reyna, Servillano B. Romasanta, Basilio F. Fernandez, Moises A.Maramba, Isidro Z. Tandoc, Jose D. Fenoy, Ruperto Z. Tandoc, Catalino C. Coquia, Federico I. Cervas, Victorino C. Daroya, Vicente de Leon, Constancio Ancheta, Pedro B. Pinero and Brigido Martinez) together to design the blueprint of the then Luzon College of Commerce and Business Administration (LCCBA).

Luis F. Samson has served as the school president since the foundation of the college.

The Commission on Higher Education granted university status to the Luzon Colleges in 2002.

The Liberal Arts, Commerce and Education (LACOMED) programs of the university are now in preparation for bids for Centers of Excellence Status.

The UL Pozorrubio Campus was opened in June 2008 with an enrollment of 46 students.