[3] Major components of the University of Maryland Medical System include: The R Adams Cowley Shock Trauma Center (also known as Shock Trauma) is the world's first center dedicated to saving lives of people with severe, life-threatening injuries sustained in motor vehicle collisions, violent crimes and other traumatic incidents.

UMCH has its own pediatric pharmacy and emergency room, and is also very active in children's health care research.

In January 2022, researchers and clinicians at the University of Maryland Medical System's flagship hospital successfully transplanted a genetically modified pig heart into a 57-year-old man, David Bennett Sr., for the first time in history.

[16] In 2019, Baltimore Mayor Catherine Pugh became the center of a controversy related to a payment of $500,000 from the University of Maryland Medical System for the purchase of her Healthy Holly self-published books.

She did not disclose the payments or recuse herself from votes and decisions involving the medical system and the wider Healthy Holly Controversy led to her resignation and eventual criminal conviction.

[17] Maryland legislative leaders and the Medical System pledged to reform the practice of giving large contracts to board of directors due to the conflict it poses to their decision-making.