Each private patient room includes a bathroom, a sleeper sofa for guests and special amenities for new mothers.

[citation needed] Mothers-to-be with high-risk pregnancies will benefit from the expansion of maternal-fetal medicine and ultrasound services connected to the hospital and located on the fourth floor of the Keene Medical Building.

[8] The University of Missouri Healthcare System is transitioning to one central campus, with plans for a Children's Tower by Summer of 2024.

Pediatric Inpatient Services, and Surgeries and Procedures have been relocated to University Hospital, until the new Children's Tower is completed.

Construction began after the land was purchased on February 7, 1972, and the new Columbia Regional Hospital and 33,000-square-foot (3,100 m2) orthopedic clinic to the south opened in 1974.

[12] In 1999 University of Missouri Health Care purchased Columbia Regional Hospital from Tenet Healthcare for $34.55 million.

More than $12 million was spent to renovate the former building including the construction of two new entrances, one child-friendly and one specifically for women.