[1][2] It is located on a 10-hectare (25-acre) site in the south of the Ciudad Universitaria, an area that houses a number of the university's cultural institutions, which is also part of the Pedregal de San Ángel ecological reserve.

[2] Universum has also worked to create extension museums in other parts of the country such as the Museo de Ciencia y Tecnología in Chiapas .

They include the José de la Herrán Planetarium, the Parákata Butterfly Exhibit, the Patli exhibit on medicinal plants, Biodiversity Hall, Mathematics Hall, Golem unit on artificial intelligence, Reduce, Reuse, Recycle, The Brain, Chemistry in Everything, The Universe, Euclid’s Window, Our City, Evolution, Life and Time, Population, Health and Sexuality.

It was created by scientists in applied mathematics from UNAM to respond with information modified to the person who is interacting with it.

[10] In 2004, it hosted robotic displays of savanna animals from Africa such as a hippopotamus waking up, an elephant calling to its child and a crocodile opening its mouth to let birds pick off remains of its meal.

[11] In 2006, an exhibit demonstrating how a virus infects a cell was created by artist and architect Antonio O’Connell, made with wood, much of which was recycled from construction sites.

[2][13][14] The museum seeks to engage the public through exhibitions, activities, workshops, conferences, classes, cinema and theater.

[3] In summer, the museum hosts classes and courses for children, divided by age group, on science topics.