When children's author Alice Tanner (Amy Irving) inexplicably suffers from a seizure during a suicide attempt, the Princeton-Plainsboro team must evaluate both her underlying medical conditions, as well as her unstable psychological state.
Meanwhile, House takes Cuddy on a double date with Wilson and his girlfriend, Sam (guest star Cynthia Watros).
Later, House suspects the screw implants were actually from a car accident, and that the seat belt damaged Alice's thyroid glands.
Helen refuses treatment until House lies and tells her that her son died from a brain aneurysm that caused the crash.
Helen refuses and House begins to tell her the truth about her son's cause of death, but he sees Cuddy in the doorway and stops.