The round was led by DFJ and also included investment from Bill Gates, Richard Branson, Suzy and Jack Welch, Cargill, Kimbal Musk, and Atomico.

[14] In September 2021, co-founder and chief science officer Genovese, as well as process development vice president KC Carswell, left the company.

[17][18] On November 17, 2022, the FDA completed a pre-market consultation process for the company to sell its cultivated chicken to the public.

[21] On April 24, 2023, Upside Foods announced a range of new products made of chicken cells, plant protein, and seasoning ingredients.

Additionally, the company developed a cell line that grows in a culture medium without platelet-derived growth factors, costing between $20,000 and $30,000 per gram.

According to the report, Upside Foods has been primarily relying on less efficient roller bottles, which require more work for a much smaller output and are incapable of cultivating full cuts of meat.