Uruaçu is located north of Anápolis and Goiânia on the important interstate highway BR-153, which links Brasília to Belém.

On the east the boundary is formed by the Serra da Mesa reservoir (43 meters deep and 1,784 km2 in area).

The origin of this town was the Passa Três ranch acquired by the Fernandes family in 1910 and located in the municipality of Pilar de Goiás along the route used by muleteers and merchants from the south.

In 1913 Coronel Gaspar donated lands to build a chapel dedicated to Saint Anne and the settlement was called Sant'Ana.

The economy is based on subsistence agriculture, cattle raising, services, public administration, and small transformation industries.