Following the dissolution of the Soviet Union, Uzbek President Islam Karimov in 1992 authorised the creation of Uzbekistan Airways.

[9] Uzbekistan Airways was the launch customer for the Ilyushin Il-114; it took delivery of the first, locally assembled aircraft, in July 1998.

Destinations served at the time included Almaty, Amsterdam, Andizhan, Ashgabat, Athens, Baku, Bangkok, Beijing, Bishkek, Bukhara, Chelyabinsk, Delhi, Dhaka, Ekaterinburg, Fergana, Frankfurt, Istanbul, Jeddah, Karshi, Kazan, Khabarovsk, Kuala Lumpur, London, Mineralnye Vody, Moscow, Namangan, New York, Novosibirsk, Nukus, Omsk, Paris, Riyadh, Rostov-on-Don, Samara, Samarkand, Seoul, Sharjah, Simferopol, St. Petersburg, Tashkent, Tel Aviv, Termez, Tyumen, Ufa and Urgench.

[16] Since its formation, Uzbekistan Airways has focused its passenger service on Western Europe and other international locations.

Uzbekistan Airways has codeshare agreements with the following airlines:[18][19] Uzbekistan Airways has interline agreements with the following airlines:[18] As of March 2020[update], the airline operates the following aircraft:[25][26][needs update][better source needed] In mid-2007, the carrier ordered six Airbus A320s; by that time the fleet was 55 strong, comprising ten different aircraft models; the Russian-built Yakovlev Yak-40 was among them.

[48][49] The airline took delivery of its first A320 in July 2010 (2010-07); the type started operations servicing the Tashkent–Baku route.

[58][59] Uzbekistan Airways previously operated the following aircraft: According to the Aviation Safety Network, as of January 2013[update] the airline experienced eight accidents and incidents throughout its history, totalling 54 reported fatalities;[60] only those involving fatalities and hull-losses are listed below.