Sprinter Guzal Khubbiyeva and trampoline gymnast Ekaterina Khilko became the first Uzbek female athletes to compete in four Olympic games.

Light heavyweight boxer and double Asian Games champion Elshod Rasulov was the nation's flag bearer at the opening ceremony.

Freestyle wrestler Artur Taymazov, who defended his super heavyweight title for the third time, became the most successful Uzbek athlete in history with a total of four Olympic medals.

On 7 November 2012, the International Olympic Committee stripped Soslan Tigiev of his bronze medal after testing positive for the prohibited substance methylhexaneamine.

[1] On 23 July 2019, the International Olympic Committee stripped Artur Taymazov of his gold medal after testing positive for the prohibited substance.