Deshpande took part in the civil resisters' mission of the Hindu Mahasabha to the Hyderabad state in March 1939, to protest against the Nizam's rule.
Deshpande managed to get elected from two Lok Sabha constituencies (Gwalior and Guna).
[7] He renounced his Gwailor seat, to enable Hindu Mahasabha president N. B. Khare to contest it in a by-election.
Deshpande lost his parliamentary seat in the 1957 general election to Rajmata Vijayraje Scindia of the Indian National Congress.
His cousin, Sumati Sukalikar, was also a leader of Bharatiya Jana Sangh in Nagpur, who contested a couple of elections unsuccessfully.