In molecular biology, the VHS protein domain is approximately 140 residues long.

[1] VHS domains are thought to be very important in vesicular trafficking, in particular, aiding membrane targeting and cargo recognition role.

[1] Resolution of the crystal structure of the VHS domain of Drosophila Hrs and human TOM1 revealed that it consists of eight helices arranged in a double-layer superhelix.

Overall, sequence similarity is low (approx 25%) amongst domain family members.

The domain is considered to have a general membrane targeting/cargo recognition role in vesicular trafficking.