Vacqueyras (French pronunciation: [vakeʁas]; Occitan: Vacairaç) is a commune in the Vaucluse department in the Provence-Alpes-Côte d'Azur region in southeastern France.

Containing many alternating little valleys of minimal depth and plains + hills to the east, (261 m to the Muse), the extremity is at the Dentelles de Montmirail.

The Dentelles de Montmirail are the furthest west of the Massif des Baronnies and constitute the first advance of the Alps into the Rhone Valley.

Rocky stones from the Late Jurassic (Tithonian) period with clay-limestone soil dominate the area.

Vines grow well on the hillsides and also on the stony flat ground, at higher levels.