[2][3] The Science Oriented Experimental Class (SOEC) was initiated in school year 1996–1997 "to shape and produce globally competitive and morally upright individuals who will serve as the foundation of [the] nation's great success.

The class was housed at the Valenzuela National High School (VNHS), in Barangay Marulas, and it was composed of 40 academically outstanding students.

At the beginning of the school year 2005–2006, VCSHS moved to its newly constructed building at A. Marcelo Street in Barangay Dalandanan.

According to the teachers at the time, a recorded shortest graduation happened for the 15 students of SOEC passing the 4th year curriculum of ValSci.

Rexlon Gatchalian, local government officials, the Valenzuela City Science High School faculty and students, and the Department of Education (DepEd) secretary Armin Luistro attended the ceremony.

[8] The mayor praised the school's NAT scores, which are the highest in Metro Manila, and the high passing rate for UPCAT.

"[5] Rexlon Gatchalian, during the tour of the newly constructed building, said, "With something as grand as this, we want to stir an interest in mathematics and science among the youth in Valenzuela City."

The four-story school building is a full Wi-Fi zone[10] and contains 20 classrooms, which can hold 35 to 40 students each,[11] and physics and robotics, speech, computer, chemistry, biology, and mathematics laboratories.

[13] Luistro said, "My prayer is that Valenzuela City School of Mathematics and Science may produce the best and brightest scientists of the country.

"[5] The Valenzuela City School of Mathematics and Science Supreme Secondary Learner Government, referred to as the VCSMS SSLG (formerly VCSMS SSG), and commonly referred as the SSLG, is the student government of Valenzuela City School of Mathematics and Science.

It is highly recommended that the batch name can be written in baybayin, but other languages such as Latin, English, or others may be accepted.

The names of the batches will printed in sablay, which is worn for photos for yearbooks and for portrait photoshoot, for both moving up to senior high school and graduation.