[1] Her research aims to identify biomarkers of breast cancer to inform diagnosis and treatment.
[10] She served as principal investigator of the Leeds Breast Cancer Campaign Tissue Bank.
[17] In 2016 Speirs launched the virtual resource Sharing Experimental Animal Resources: Coordinating Holdings in Breast Cancer (SEARCHBreast), a platform to share materials that are surplus to animal studies of breast cancer.
[18][19][20] The project was part of a NC3R grant to develop smart approaches to reduce animal use in science.
She is a member of the Cellular Molecular Pathology initiative of National Cancer Research Institute.
[23] They will investigate how endocrine disrupting agents modulate the activity of fibroblasts in high and low mammographic density breast tissue.
[citation needed] Speirs was elected a Fellow of the Royal College of Pathologists (FRCPath) in 2007.