There is no information about the Valle Romita Polyptych's origins; however, it may have been commissioned by the lord of Fabriano, Chiavello Chiavelli, when in 1406 he had the local convent restored to house his future tomb.

The presence of elements of the International Gothic style, in particular as practiced by Michelino da Besozzo (such as the accurate rendering of natural details) has led some to narrow the dates to 1410-1412, when the two artists met in Venice.

The central panel depicts the Incoronation of the Virgin and, in the lower part, a Trinity and a choir of musician angels.

This scene was inspired to the Byzantine mosaics that Gentile had seen at Venice in St. Mark's Basilica, as shown by the figures floating in the air and the shining gold background, which is very finely tooled.

Other small panels with saints, divided among several collections, have been also thought to be once in the side piers of the polyptych, now lost.