Vanadium(V) oxytrifluoride is a chemical compound with the formula VOF3.

[2] Characteristic of early metal fluorides, the structure is polymeric in the solid state.

The solid adopts a layered structure but upon evaporation, the species becomes dimeric.

In contrast VOCl3 and VOBr3 remain tetrahedral in all states, being volatile liquids at room temperature.

[3] In organic synthesis, VOF3 is used for the oxidative coupling of phenols, for example in the syntheses of vancomycin and its analogues.