Vasco de la Zarza may have been born in Toledo, although others have considered him of Portuguese origin.
He is believed to have taken a trip to Italy in his youth, which would have enabled contact with Italian Renaissance art, which is seen as an influence in his style.
His most important work is the tomb with Alonso Fernandez de Madrigal (1518) made of alabaster.
In the four side panels, framed by richly ornate and simple cover, the four evangelists in the act of writing, there are over roundels with representations of saints and, above them, several scenes from the life of Christ.
His latest work documented in Ávila in 1522, is the tabernacle of the main altar, carved in alabaster, with scenes of the Passion.