Xanthopoulos grew up playing for the youth teams of the Greek club Olympiacos Piraeus.

Xanthopoulos started his professional career with the Greek Basket League club Near East in 2002.

In 2006, Xanthopoulos returned to Panathinaikos Athens, and with them he won the European Triple Crown in 2007.

[3] On July 5, 2017, Xanthopoulos moved to AEK Athens of the Greek Basket League, where he signed a one-year contract, with the option of renewal for another season.

In 17 games, he averaged 4.2 points (shooting with 36% from the 3-point line), 2.4 rebounds, 4.9 assists and 1 steal in 20 minutes per contest.

On August 29, 2022, Xanthopoulos returned to AEK for a second stint, following his Kolossos head coach Ilias Kantzouris to the team.

On July 29, 2023, Xanthopoulos returned to Peristeri, under head coach Vassilis Spanoulis.