Vasilopoulos was born in Maroussi, Athens, and grew up at his hometown of Ano Samiko Elis.

On May 20, 2008, he extended his contract with Olympiacos for another 4 years, at a salary of €6 million euros net income.

On February 8, 2012, Vasilopoulos suffered a season-ending leg injury, just after he had returned from a previous back surgery.

[6] After being released by Valladolid in December 2013, Vasilopoulos then signed with the amateur level Greek club Ermis Piraeus, in April 2014.

[8] On July 26, 2017, Vasilopoulos signed with the Greek club Aris Thessaloniki, and played with them in the FIBA Champions League's 2017–18 season.

[10] With AEK, he won the 2018 Final of the Greek Cup, as well as the FIBA Champions League championship.

On July 27, 2018, Vasilopoulos signed a 2-year contract with Peristeri of the Greek Basket League, where he eventually became the team captain.

In July 2022, he renewed his contract and stayed on as an assistant to his former national squad and Olympiacos teammate Vassilis Spanoulis.