Veinticinco de Mayo is a town in the Florida Department of southern-central Uruguay.

The stream Arroyo Isla Mala, tributary of Arroyo Santa Lucía Chico, flows along the west and north limits of the village, forming a lake or wetland to the east side of it.

Its original name was "Isla Mala" and it was recognized as a recently created populated centre by a decree of 1 September 1875.

It was renamed to its present name and declared a "Pueblo" (village) on 17 July 1918 by the Act of Ley N° 6.196.

[1] Its status was elevated to "Villa" (town) on 28 January 1985 by the Act of Ley N° 15.706.