Velikiye Luki Oblast was established on 22 August 1944, one day before Pskov Oblast, to administrate areas of Soviet Union previously occupied by German troops and liberated in the course of World War II.

On 10 March 1945 four more districts, Podberezinsky (with the administrative center located in Podberezye), Porechensky (Porechye), Prihabsky (Prikhaby), and Zharkovsky (Zharkovsky), were established.

In 1952, Ust-Dolyssky District with the center in the selo of Ust-Dolyssy was established.

The following persons were the first secretaries,[2][3] On 2 October 1957 Velikiye Luki Oblast was abolished.

[1] Belsky, Ilyinsky, Leninsky, Nelidovsky, Oktyabrsky, Penovsky, Seryozhinsky, Toropetsky, and Zharkovsky Districts were transferred to Kalinin Oblast, and all other districts were merged into Pskov Oblast.