Tithorea (Neon), is the starting point and co-founders, along with other cities in the Boeotian Kifissos, Phocaea, a colony on the coast of Asia Minor, opposite Chios, under the Athenian Philogenes.

The Tithorians, along with the other Phocians, were the only ones from the central and northern Greek states who did not get the side of the Persians when Xerxes marched against Greece and participated with a remarkable army in the battle of Thermopylae.

Varying opinions have arisen from Herodotos' statement, that a number of Phocians fleeing Xerxes took refuge on the isolated peak of Tithorea, near Neon.

The people of Velitsa (Tithorea), took part, with a 47-member percussion group members, during the battle of Arachova on November 18 and 24, 1826, as well with  a lower participation under Sergeant Vagenas and Athanasakos, at the exit of Messolonghi.

Tithorea was the origin of the admiral of independence, Russian army officer, Catherine the Great, Empress of Russia lover Lambros Katsonis.

Tithorea in the post-liberation period and prior to that name Velitsa, was established on 18.10.1835, as a settlement of the prefecture of Attica and Boeotia.During the German-Italian occupation, the Velitsiotes, along with the other villages, took part in one of the largest sabotages in central Greece, in Palavitsa, between Amfikleia-Tithorea, on April 16, 1943, which cost Rommel the supply, for 12 days and influenced the development of World War II.

Velitsa (Tithorea) was looted, the village was burned, in retaliation for the sabotage in Palavitsa and by indiscriminately firing, killed the people of Velitsa: Gazis Christos father's name Andreas, Kaperonis Ioannis fathe's Konstantinos, Trifylli Kalliopi of fatner's name Ioannis, Stafyla Panayiou and the teacher Yiannis Galanis.

The economy of Tithorea was predominantly tobacco-producing, livestock-based, with mills, a class of food merchants, shoemakers, barbers, tailors, craftsmen, builders and ironworkers.

A recent comparison of the genetic sample of Phocaeans and French from Provence and Corsica shows that one in ten men in southern France comes from colonized Greek Phocians, Phocaeans.According to Herodotus, inhabitants from ruined cities located on the banks of the Cephissus fled to the foot of the Parnassus around Tithorea.