Venom-induced consumption coagulopathy

Venom-induced consumption coagulopathy (VICC) is a medical condition caused by the effects of some snake and caterpillar venoms on the blood.

[1] Important coagulation factors are activated by the specific serine proteases in the venom and as they become exhausted, coagulopathy develops.

[5] Venom induced coagulopathy may also be accompanied by a thrombotic microangiopathy consisting of thrombocytopenia (low platelets), microangiopathic hemolytic anemia and acute kidney injury.

The anticoagulation effects of snake venom can last for up to two weeks in some species without the administration of antivenom and should thus be considered as the relevant time course when distinguishing symptom causes.

General principles of treatment also include application of pressure dressing, baseline blood tests, swabbing of bite site for venom, urinalysis, and follow-up serial bloodwork to monitor disease progression.