[1] A right ventricular outflow tract obstruction (RVOTO) may be due to a defect in the pulmonic valve, the supravalvar region, the infundibulum, or the pulmonary artery.

[4] When the heart has to pump against increased resistance, or afterload, as in the case of a ventricular obstruction, it compensates by growing in size.

This adaptation is beneficial to pump blood past the obstruction, but eventually this hypertrophy can lead to other problems including arrhythmias, ischemia, and heart failure.

[5] In hypertrophic cardiomyopathy, there is disorganized production of cardiac myocytes leading to increased septal wall thickness and a pathologic motion of the mitral valve.

If severe enough, this condition requires prompt treatment, as these patients are at risk for lethal tachyarrythmias.