Shukrullo Mirsaidov was the first and only holder of the office from 24 March 1990 to 8 January 1992.

[2][3] The position of vice president was introduced on the same day Islam Karimov was elected President of the Uzbek SSR on March 24, 1990 at a session of the Supreme Council of the Uzbek SSR.

The only person who served as vice president was Shukrullo Mirsaidov, who, before this position, was the Chairman of the Council of Ministers of the Uzbek SSR.

[4] The main function of the vice-president of Uzbekistan was to, in the case of the president's incapacitation, death or resignation and until early elections, assume presidential powers as acting president At the same time, the vice-president of Uzbekistan, jointly headed the Cabinet of Ministers with the president.

Nowadays, article 96 of the Constitution of Uzbekistan states that should the President of the Republic fail to perform his duties due to poor health, confirmed by a certificate of a State Medical Commission formed by the Supreme Assembly of Uzbekistan (Oliy Majlis), an emergency session of the Oliy Majlis shall be held within ten days.