Vicente de Azcuénaga Iturbe (January 1706–1787) was a Spanish-born Argentine businessman and politician.

From Durango, Vizcaya, Spain, he arrived in Buenos Aires in his early forties and was devoted to commercial activities.

He proved to be a successful trader which enabled him to amass a small fortune in a short time.

He maintained a strong friendship with Francisco Ugarte, another great merchant of the time.

Vincent de Azcuénaga had seven children, three of whom spent time in the Argentine military, while another was an attorney.