He was on the editorial board of Mathematical Biosciences and was a founder of Softberry Inc.. Solovyev works with developing statistical approaches, machine learning algorithms, computational platforms and bioinformatics tools for high-throughput biological big data analysis.

[citation needed] Solovyev joined KAUST in 2013 as Professor in the Computer, Electrical and Mathematical Sciences and Engineering Division.

He also held positions as assistant professor at Baylor College of Medicine, computational scientist at Amgen Inc., visiting scientist at Supercomputer Center, Florida State University, visiting professor at ITBA (Milan, Italy) and a group leader at the Institute of Cytology and Genetics in Novosibirsk, Russia.

[citation needed] About 100 software applications implemented as standalone programs or combined in pipeline or packages, have been developed under his guidance.

For example, the Fgenesh eukaryotic gene identification program has been used or cited in more than 3,000 scientific publications, according to Google scholar data.