Wilkinson displayed significant talent as a junior, winning national fell running titles at under-16 and under-18 level.

[3] A knee injury interrupted Wilkinson’s running career and she turned her attention to cyclo-cross, in which she competed at the World Championships.

[12] Wilkinson won the Šmarna Gora Race in Slovenia in 2007, the victory giving her enough points to finish second overall in the World Mountain Running Association Grand Prix that year.

[30] Wilkinson's victories in 2018 included a new fastest time at the Kentmere Horseshoe in July[31] and a win at Burnsall in August where she broke the long-standing record which had been held by Carol Greenwood since 1983.

[32] Wilkinson followed this with a new record of 1:43:01 in the Ben Nevis Race[33] and two weeks later earned the silver medal in the Ring of Steall Skyrace at the Skyrunning World Championships.