It was built in 1565 for the Doge Ambrogio Di Negro o for his son Orazio, in a coastal area that used to be outside of the city walls.

[1] In the 19th century the villa hosted famous guests, including Caroline of Brunswick, wife of George IV of the United Kingdom (1815), Pope Pius VII (1836), Honoré de Balzac and Lorenzo Pareto.

The original setting has radically changed as a result of the urbanization of the area and, in particular, of the construction of the Turin-Genoa railway in the 19th century, which led to the loss of the garden at the sea side.

[1][2][3][4] The original appearance of the 16th-century villa, testified by an 18th-century engraving, featured a facade with loggias, architectural structures and large statues attributed to Giovanni Andrea Ansaldo.

[1] The internal decoration preserves original 16th century elements, such as the portals, the frescoes in the piano nobile showing the achievements of Doge Ambrogio Di Negro against the Corsicans, and the grotesque paintings in the other rooms.