[1] He was born the son of Ascenso Santucci and Clorinda Mazzetti in Gorga in the region of Lazio, then part of the Papal States, now in the Province of Rome.

[2] As a young man, Santucci completed his higher education at the Pamphilio College, after which he was ordained as a Catholic priest at an unknown date.

In 1832 he began a career in the papal diplomatic corps, serving as secretary to Cardinal Placido Zurla, O.S.B.

[2] Santucci was named a Cardinal Deacon by Pope Pius IX in the consistory of 7 March 1853 and was given as his titular church that of Santi Vito, Modesto e Crescenzio from 1853 to 1854, when he was granted a change to holding the Basilica of Santa Maria ad Martyres, better known as the Pantheon.

[1] Santucci died in Rome at the age of 65 and, at his request, was buried in the Archbasilica of St. John Lateran.