The route starts as a four-lane divided highway and within 0.2 miles (0.32 km) of its southern terminus, it has an interchange with the US 29 freeway.

SR 41 passes through the unincorporated communities of Mount Hermon and Pleasant Gap, where the highway crosses White Oak Mountain.

The route was truncated to its present northern terminus at SR 57 in 1949 due to low traffic counts.

[7] In August 1962, the Commonwealth Transportation Board (CTB) approved a motion to drop the 0.92-mile-long (1.48 km) segment of SR 41 between North Main Street (US 29) and Piney Forest Road (what was then Alt.

The project (later renamed to East Franklin Turnpike and renumbered to be a part of SR 41) was completed in late 2011 at a cost of US$19,000,000.