Known as Prices Fork Road, the state highway runs 1.35 miles (2.17 km) from U.S. Route 460 (US 460) east to US 460 Business within Blacksburg in northern Montgomery County.

SR 412 connects US 460 with downtown Blacksburg and the northern end of the campus of Virginia Tech.

SR 412 begins at a partial cloverleaf interchange with US 460, which bypasses the center of Blacksburg to the west.

The state highway continues between a residential area to the north and several parking lots on the university campus to the south.

SR 412 reaches its eastern terminus at a three-legged roundabout with US 460 Business (Main Street) near the Odd Fellows Hall at the north end of downtown Blacksburg.