Aparajita aka Appu is born as a Vishkanya, a venomous girl, whose body and bodily fluids are poisonous and could prove fatal for anyone on contact.

Initially she was not aware of the fact that she was a poisonous girl or that she was used as a pawn to destroy the Mittal family by her maternal aunt, Kalpana Ghosh, who she believes to be her mother.

Kalpana swore revenge Nandita Mittal by planning to make Malay fall in love with Appu and then dispose of him later.

In the end, Malay reluctantly marries Vardaan due to some misunderstanding caused by his mother and under the influence of the rest of his family.

In the sequence of events, Malay has a change of heart and begins to love Vardaan, much to Appu's dismay as he instantly breaks up with her after that.

By some tricks she had up her sleeves and with Kalpana's aid, Appu manages to marry Malay but at this point he does not love her anymore and still remains unaware of her supernatural identity.

The show takes a 3-month leap and introduces Mandira, Nandita's sister who is killed by Kala Saaya.

Kala Saaya takes Mandira's form and comes to the Mittal Mansion where she kills Chiki, Avi's fiancée.

Appu scratches it but nothing happens, then Baba tells her that Goddess has taken her venom out of her body in return of Kala Saaya’s death and now she can live in peace.