[13] A debunked urban legend claims that a few drops of Visine will cause harmless but debilitating bouts of explosive diarrhea, similar to a laxative.

[15] There have been multiple high-profile murder cases that have been alleged to utilize Visine's active ingredient tetrahydrozoline hydrochloride as a poison.

[18] In the film Wedding Crashers, the character Sack Lodge, portrayed by Bradley Cooper, is drugged with Visine eye drops, and is depicted as having severe gastrointestinal upset afterwards.

The character John Beckwith, portrayed by Owen Wilson, uses Visine several times over the course of the film to feign crying.

[19] The urban legend about Visine inducing severe diarrhea is perpetuated in the film I Hope They Serve Beer in Hell.