The first prototype were built in 1990, but the B10B wasn't launched until the 1992 Geneva Motor Show.

For stage use it was gradually succeeded by the low-entry B10BLE, which was introduced only a year later, though not in all markets.

For interurban use the B7R came as a gradual replacement in 1998, and ultimately for coach work, the B12B took over in 2001.

The B10B was not generally available with a natural gas or biogas engine, like the B10BLE, but two buses were bodied by Vest Karosseri for NSB Biltrafikk in Stavanger in 1998 and 1999.

In the United Kingdom, the B10B was purchased in large numbers by GM Buses North, Merseybus, Oxford Bus Company, Trent and Yorkshire Rider.