[12][13] On June 14, 1922, U.S. President Warren G. Harding's speech at the dedication of the Francis Scott Key Monument at Fort McHenry was broadcast by the station.

[16][17] The new station's call letters, WFBR, were also randomly assigned from the sequential list of available call signs; other new stations licensed the same month included WFBK (Hanover, New Hampshire), WFBL (Syracuse, New York), WFBM (Indianapolis, Indiana), WFBN (Bridgewater, Massachusetts), WFBQ (Raleigh, North Carolina), WFBT (Pitman, New Jersey) and WFBU (Boston, Massachusetts).

WFBR was a CBS Radio Network affiliate and was played Top 40 music with a solid news department and extensive local sports coverage.

The station had its studios on East 20th Street in Baltimore City, and a transmitter site on the south side of the mouth of the Patapsco River off Waterview Avenue.

[26] The award-winning[citation needed] program covered news topics of local, state, and national interests and was moderated by station general manager Harry Shriver.

Regular panelists included WFBR newscasters Tom Marr, Ron Matz, Ken Matlath, and station program director Norm Brooks.

In the 1970s, WFBR's on-air talent featured popular personalities such as "The Flying Dutchman" Pete Berry; Ron Matz, and his fictitious alter-ego, "Harry Horni"; Johnny Walker, a wildly popular morning DJ who was "cutting edge" for his time; "The Coach", Charley Eckman, a former NBA basketball coach and referee, who later became a Baltimore sportscasting legend;[27] and a young but versatile, broadcaster named Tom Marr who pulled triple duty as the station's news director, morning news anchor, and reporter, while also working as a sportscaster for the CBS Radio Network.

After the 1982 season, Chuck Thompson moved from the radio booth to do the TV broadcasts full-time on WMAR-TV, with Brooks Robinson.

By this time, WFBR switched to a "news/talk-radio" format;[26] in addition to Tom Marr, hosts on the station during this period included Alan Christian, Les Kinsolving, Joe Lombardo, former Baltimore TV anchor Frank Luber, and Stan "the Fan" Charles.

[26] In 1988, WFBR was sold to Infinity Broadcasting (owners of crosstown WLIF), switched to an oldies format, and let go all the on-air personnel from the previous ownership.

This station focused on artists like Elvis Presley, Everly Brothers, Crystals, Fats Domino, Ricky Nelson, Frankie Lymon, The Drifters, Jackie Wilson, Roy Orbison, early Motown music, and others.

On January 15, 1990, WFBR dropped the business news format, and began simulcasting WLIF, which was about to switch from beautiful music to soft adult contemporary.

[30][31] When the Cleveland Browns relocated to Baltimore in 1996 and became the Ravens, WJFK (AM) was named as the football team's radio flagship station, with games simulcast on WLIF, and later, WQSR.

Longtime WMAR-TV sports anchor Scott Garceau was named the lead play-by-play man, with former Baltimore Colts running back Tom Matte as the color commentator.

To fill the gap in the team's coverage, WJFK and sister station WHFS aired Baltimore Gameday Uncensored throughout the 2006 season; the show was hosted by former Ravens announcers Scott Garceau and Tom Matte.

WJZ also carries University of Maryland, College Park sporting events, whose rights were previously held by rival station WBAL.

While CBS shareholders retained a 72% ownership stake in the combined company, Entercom was the surviving entity, separating WJZ radio (both 1300 and FM 105.7) from WJZ-TV.

[37][38] On June 21, 2021, WJZ flipped to sports gambling, branded as "The Bet Baltimore", with programming from the co-owned BetQL Network.