The station was first opened as Waddesdon Manor by the Metropolitan Railway on 1 January 1897.

The station was closed on 6 July 1936[2] when their services were curtailed at Aylesbury.

[1] While open, the station was also served by former Great Central Main Line (running on the same tracks as the Metropolitan line as far as Quainton Road) which was not itself closed to passengers until 1966, under the Beeching Axe.

Until 2021 the line was used for a daily freight train carrying waste from London to Calvert, as well as special services between Aylesbury and Quainton Road for events at the Buckinghamshire Railway Centre.

Because of its association with the Metropolitan line this station is considered to be one of the Closed London Underground stations although it is 42.5 miles (68.4 km) from London and is not underground.