It is formed by the confluence of its North and South forks just west of Wailua and enters the Pacific Ocean at 22°2′42″N 159°20′11″W / 22.04500°N 159.33639°W / 22.04500; -159.33639 (Mouth of Wailua River).

It is the only navigable river[2] (by boats larger than kayaks) in the Hawaiian Islands.

It is a center of activity for locals and visitors in the form of boat tours to Fern Grotto, kayaking and water skiing.

The South Fork forms at the junction of several streams southwest of Hanamaulu and flows 8.1 miles (13.0 km) east,[1] over Wailua Falls, to its junction with the North Fork.

Other points of interest along the river system include a bird refuge, Kamokila Hawaiian Village, Secret Falls and a pool which formerly included a rope swing.