The second station in the town is Warrington Bank Quay, which accommodates electrified lines on the West Coast Main Line with services to London Euston, Birmingham New Street, Liverpool Lime Street and Glasgow Central.

[a][2][3] The station is located on a raised embankment on the eastern side of where the line crosses Winwick Street, on the northern edge of the town centre.

[3][5] The original station building, which faces away from the town and is not easily seen by passengers, is an impressively long one-storey fine Italianate building of twenty bays in yellow brick with decorative stonework, numerous rusticated round-headed windows, a projecting central block with balustrades.

[13][14] It was replaced in 1897 by a larger building set further back from the main lines, on the site of the original goods platform.

The dominant feature of the warehouse is the series of large concrete panels under the roofline displaying the name of the CLC and its owning companies.

[16] There were several cattle pens to the north-west of the goods yard and several short sidings immediately to the east of the passenger station.

[16] Sometime prior to 1893 a single road engine shed was provided to the south of the station, immediately behind the Liverpool bound platform.

The station has a customer service office, toilets, waiting rooms, a newsagent and a coffee stall.

[23] As of the May 2023 timetable, an average of eight trains an hour stop at Warrington Central at off-peak times.