The highway linked Fort Simcoe State Park in the west to White Swan and Toppenish in the east.

The highway passed over a BNSF Railway rail line, formerly part of the Toppenish, Simcoe & Western Railroad, before Curtis street turned easterly and became Fort Road.

[4] The highway was first constructed some time between 1915 and 1937,[5] with a segment linking Fort Simcoe to White Swan completed by 1937.

[9][10] SR 220 was considered for removal in 1986 by a legislative committee with input from the state, counties, and city governments.

[13][14] The city of Toppenish is eligible to receive hardship funding for the former highway between the junction with SR 22 to near Linden Road, a span of .27 mi (430 m).