Except for the section through Toppenish and the southeastern bypass of Prosser, the highway is lightly traveled passing mainly through rural farmland.

The route heads south through farmland towards the town of Toppenish in Yakima County, which is also part of the Yakama Indian Reservation.

[5] SR 22 serves as a bypass of Prosser, turning north until intersecting Wine Country Road on the east side of Prosser before turning back southwest on Wine Country Road and terminating at a folded diamond interchange, exit 82, on I–82.

[17] In Spring 2011, WSDOT began a $4.63 million construction project to build wider lanes and shoulders on SR 22 between I-82 and the city of Toppenish, because of a number of collisions along the roadway.

Other improvements included installing new sidewalks with ADA-compliant curbs and access ramps, as well as adding turn lanes to side roads.