Wayne is a town in McClain County, Oklahoma, United States.

Wayne and McClain County are part of the Oklahoma City Metropolitan Area.

[citation needed] The town was significantly damaged by an EF2 tornado on December 13, 2022.

[5] According to the United States Census Bureau, the town has a total area of 0.4 square miles (1.0 km2), all land.

The town also has Mid-America Technology Center, a Vocational School and College.