Wayne Anthony Simien Jr. (born March 9, 1983) is an American former professional basketball player, who last played with Spain's Cáceres Ciudad de Baloncesto.

Simien played in college at the University of Kansas, where he was a consensus first-team All-American his senior year in 2005.

He committed to play for Roy Williams and the University of Kansas as early as the 8th or 9th grade, and was later named to the 2001 McDonald's All-American Team.

During his high school career, he began working with world-renowned conditioning coach Istvan Javorek.

Simien was traded from the Heat along with Antoine Walker and Michael Doleac to the Minnesota Timberwolves on October 24, 2007, for Ricky Davis and Mark Blount.

[5] He was given a Summer League invitation by the Cleveland Cavaliers, but did not play due to a hamstring injury.