Waynesboro (/ˈweɪnzbʌroʊ/) is a city in Wayne County, Mississippi, United States.

[4] The discovery of oil in Wayne County during the 1940s drove an economic and population boom.

As of the 2020 United States Census, there were 4,567 people, 1,786 households, and 1,219 families residing in the city.

As of the 2010 United States Census, there were 5,043 people living in the city.

29.6% of all households were made up of individuals, and 12.1% had someone living alone who was 65 years of age or older.

The city is served by the Wayne County School District.

[11] The city's high school level education is provided by Wayne County High School (public) and Wayne Academy (private).