It features guest appearances from Strong Arm Steady, Jelly Roll, Busta Rhymes and Keri Hilson, and contributions from Butch Cassidy, Dion Jenkins, Dontae Winslow, Mashica Winslow, Suga Free, Tone Trezure, Truth Hurts and Dee Ray.

[1] Steve Juon of RapReviews found "the only thing really disappointing about Weapons of Mass Destruction is that Xzibit seems to have once again forsaken his Alkaholiks homies".

[6] Vibe critic called the album "brimming with energy and depth", while Blender reviewer stated: "Xzibit reinvents himself as a rapper invigorated by current events".

In mixed reviews, Dotmusic critic wrote: "ethical incontinence notwithstanding, Xzibit is an undeniably charismatic vocalist, with a gift for pure, jolting, testosterone-packed aggression that leads to some rather magnificent moments".

Christian Hoard of Rolling Stone found it "dragged down by too much unremarkably brawny fare" and marked "Cold World" as a key song.