Weber taught at the University of Utrecht then participated in an expedition to the Barents Sea.

His discoveries as leader of the Siboga Expedition led him to conclude that Wallace's Line was placed too far to the west.

As is the case with plant species, faunal surveys revealed that for mollusks[3] and most vertebrate groups Wallace’s line was not the most significant biogeographic boundary.

[5] Weber became member of the Royal Netherlands Academy of Arts and Sciences in 1887.

[8] Weber Deep with a depth of 7,351 meters, (24,117 feet, 4.56 miles) in the Banda Sea.