The men's +105 kg competition of the weightlifting events at the 2011 Pan American Games in Guadalajara, Mexico, was held on October 27 at the Weightlifting Forum.

[1] The defending champion was Cristián Escalante from Chile.

Escalante was scheduled to compete, however withdrew after testing positive for drugs.

[2] Each lifter performed in both the snatch and clean and jerk lifts, with the final score being the sum of the lifter's best result in each.

This weightlifting event was the heaviest men's event at the weightlifting competition, limiting competitors to unlimited amount of kilograms of body mass.