The chef de mission for the United States for these Pan American Games was Alan Ashley, the USOC's Chief of Sport Performance.

[3] The city of Houston, Texas, served as the processing center for athletes participating in the 2011 Pan American Games.

[6] *-Indicates athletes that participated in the preliminaries but not the finals * – Hicks finished 4th in the competition but the original gold medalist, Víctor Castillo of Venezuela, was disqualified on November 9, 2011, after he tested positive for performance-enhancing drugs.

[8] The United States has qualified a baseball team of twenty athletes to participate.

Final rank: Both the men's and women's teams of the United States qualified for the basketball tournament automatically.

Final rank: 7 The United States has qualified a total of six athletes for four of the ten basque pelota events.

[17] Bill O'Neill and Chris Barnes were the top competitors at the qualification trials and had excellent performances at the USBC Masters and the US Open of Bowling.

[17][18] The United States will be represented by Kelly Kulick and Liz Johnson in the women's bowling competition.

[23] The United States has qualified three female athletes to compete in the road cycling competition.

The United States qualified three athletes, two male and one female, to compete in the mountain biking cycling competition.

The United States qualified four athletes, two male and two female, to compete in the BMX cycling competition.

[25] Following is the short list released by the USEF on July 27, including substitutes:[24][25] Following is a list of the final nomination of the USEF and the official entries into the Pan American Games:[26] ^1 The final score is based on the Grand Prix for the team event and the Grand Prix Special and Grand Prix Freestyle for the individual event.

The United States will send representatives to participate all fourteen events of the rowing competition.

The finalized list of crews chosen to represent the United States was announced on September 27.

Final rank: The United States qualified three male and three female athletes to compete in the individual and team tournaments.

The United States will send a team to Guadalajara based on performances at the 2011 ConocoPhillips USA Swimming National Championships in Palo Alto, California, serving as the official selection meet for the 2011 Pan American Games United States swimming team.

[48] The National Championships were held in early August and USA Swimming announced the representatives.

The United States has qualified a team and a duet to participate in the synchronized swimming competition.

[50] The United States can qualify individual men's athletes through a special qualification tournament.