Wescosville is a census-designated place located in Lehigh County, Pennsylvania.

[5] Wescosville is located in south-central Lehigh County in the northern corner of Lower Macungie Township.

The primary business district of Wescosville runs along Hamilton Boulevard and is bisected by the Pennsylvania Turnpike Northeast Extension (I-476), also known as the Northeast Extension of the Pennsylvania Turnpike.

I-78 East proceeds 92 miles (148 km) to the Holland Tunnel's entrance to Lower Manhattan.

Wescosville is home to a park and ride lot at the site of the former Charcoal Drive-In restaurant on Hamilton Boulevard that serves Trans-Bridge Lines and Klein Transportation buses to Midtown Manhattan in New York City.