The western edge of the mesa is the Rio Puerco near the Laguna Pueblo about 20 miles (32 km) west of Albuquerque.
A large portion of the West Mesa is part of Petroglyph National Monument and is bisected by Interstate 40 and Historic Route 66.
Atrisco Vista (previously named Paseo del Volcan) (NM 347) runs north-south on the West Mesa, connecting I-40/US-66 to Double Eagle II Airport.
The Bernalillo County Correctional Facility, Cerro Colorado Landfill, and the Sandia Motor Speedway are located on the West Mesa, several miles south of Interstate 40.
The National Weather Service operates a WSR-88D NEXRAD radar site on the West Mesa near Double Eagle II Airport.